INGREDIENTS of ZETACAP
Below is a list of ingredients and a summary of their affects; however, I
highly recommend reading the underlined links provided for a thorough examination of each herb.
Cassia Angustifolia
(Senna)
Drug Digest (summary below)
Summary
Senna is an effective laxative ingredient in several commercially-available
non-prescription products.
Risks
Senna should be avoided by individuals with gastrointestinal conditions including
hemorrhoids, ulcers, and unexplained abdominal pain. It should not be given to children under the age of 5 years.
Side Effects
Taking senna for longer than a week or two may result in low potassium levels,
laxative dependence, or symptoms such as:
- Clubbed fingers
- Joint pain
- Loss of weight due to decreased appetite
- Weakened bones or muscles
Occasional use of senna may result in cramps, diarrhea, or discolored urine.
Senna can cause a significant decrease in potassium, which can cause changes
in heart rhythms, increase cramps, and muscle weakness.
Interactions
Taking senna at the same time as drugs or herbals with laxative or diuretic
effects may cause potentially dangerous reductions in the amount of potassium in the body. Senna may also increase the risk
of side effects from digoxin.
Capsicum Frutescens
(Cayenne Pepper)
Drug Digest (summary below)
Purdue University
Summary
In the United States, capsicum is used mainly as a topical product to relieve
pain and sometimes itching. By mouth, it has some usefulness in digestive conditions such as indigestion. It has also been
taken to relieve nasal congestion and headaches. It may also have a role in add-on treatment for diabetes and obesity.
Risks
Individuals who are allergic to hot peppers, those with GI conditions, children,
and women who are pregnant or breast-feeding should avoid taking supplemental amounts of capsicum by mouth. Individuals with
allergies to latex or tropical fruits may also have capsicum allergy. After handling capsicum plants or applying topical forms
of capsicum, the hands should be washed carefully and the eyes and face should not be touched. If a rash or intense pain occurs,
topical capsicum should be stopped.
Side Effects
In rare reports, very large amounts of capsicum or capsicum taken by mouth
for very long amounts of time have been associated with liver or kidney damage. Orally, capsicum may irritate the stomach,
worsening inflammatory or infective stomach conditions. The eyes, mouth, nose, and throat may also be irritated, producing
results such as a runny nose and watering eyes.
Topical forms of capsicum may cause burning or itching at the places they
are applied. They should be applied only to unbroken skin.
Interactions
Oral capsicum can interfere with prescription and non-prescription drugs
and other herbal products that:
- Act as anticoagulant or antiplatelet agents
- Cause sedation
- Inhibit monoamine oxidase
- Lower blood pressure
- Suppress stomach acid (thereby causing heartburn)
Plantago Major (Psyllium)
Drug Digest (summary below)
Purdue University
Summary
Psyllium’s main use is to treat or prevent constipation, but it may
also relieve diarrhea and other gastrointestinal conditions, such as irritable bowel syndrome. Taking it may help reduce cholesterol
and blood sugar levels.
Risks
Psyllium that has not been processed properly may contain chemicals that
could cause kidney damage. Individuals with kidney conditions should only use psyllium with the supervision of a healthcare
professional. Individuals with conditions that could restrict the esophagus or intestines should avoid psyllium, and individuals
with diabetes may want to take sugar-free psyllium products and monitor their blood sugar more closely.
Side Effects
If adequate liquid is not taken with psyllium, esophageal or intestinal blockage
is possible. Psyllium may also cause gas or bloating and individuals who are especially sensitive to it may have allergic
reactions.
Interactions
Psyllium could reduce the absorption, and therefore the effectiveness,
of drugs, herbal products, or foods (thereby nutrients from food). Effects of the drugs lithium and carbamazepine seem
especially to be decreased. Drugs and herbals that lower blood sugar may be more effective, however, if psyllium is taken
at least one hour after or 4 hours or more before the drug is taken.
Xanthum Gum
Xanthum Gum Powder is milled from the dried cell coat of a laboatory-grown
microorganism, Xanthomonas campestris. It is in cosmetics to thicken lotions and creams and also in gluten-free cooking
as a substitute for gluten in yeast breads and other baking with gluten-free flours.
It is produced by a fermentation process using corn or soya starch (GMO Free)
and a micro-organism (Xanthomonas Campestris). The starches and the organism react together, in a similar way to yogurt making.
The gum produced is then milled to produce an easy to use flour. It is particularly useful when baking using gluten free flours
as it mimics the effects of gluten without any of the side effects. Also known as E415, it has been widely used in the food
industry for many years. There are no side effects that we are aware of. (Various online sources)
Fucus Vesiculosus
(Seaweed (Bladderwrack))
Vitacost (summary below)
Holistic Online (summary below)
Remedies For:
Anti-hypothyroid, anti-rheumatic, alterative, diuretic
Bladderwrack has proved most useful in the treatment of underactive thyroid
glands and goiter. Through the regulation of thyroid function there is an improvement in all the associated symptoms. Where
obesity is associated with thyroid trouble, this herb may be very helpful in reducing the excess weight. It has a reputation
in helping the relief of rheumatism and rheumatoid arthritis, both used internally and as an external application upon inflamed
joints.
Fucoidan is another
type of dietary fiber in bladderwrack that contains numerous sulfur groups. According to test tube and animal studies, this
appears to give fucoidan several properties, such as lowering LDL cholesterol levels,10 lowering blood glucose
levels,11 anti-inflammatory activity,12 possible anticoagulant effects,13 and antibacterial14
and anti-HIV activity.15 People who are allergic to iodine may need to avoid bladderwrack.
Konjac Radix (Devil's
Tongue)
Drug Digest (summary below)
Summary
Glucomannan, the fiber obtained from the tubers of the konjac plant, is used
mainly as a laxative. It may also encourage weight loss, help to lower blood sugar levels, and lessen cholesterol in the blood.
Risks
Individuals with diabetes should not take glucomannan due to possible changes
in blood sugar that it may cause. Children under the age of 5 and women who are pregnant or breast-feeding may want to avoid
using glucomannan, as well.
Side Effects
In tablet form, glucomannan has been associated with esophageal blockages.
(Product must be taken with plenty of water due to the possibility of the pill swelling in the throat when the pill absorbs
the water)
Interactions
Glucomannan's potential decreasing effect on blood sugar may interfere with
drugs or herbs that also lower blood sugar. Since Glucomannan cannot be digested, foods, herbals, and drugs may not be absorbed
through the stomach so avoid use of drugs or herbals within 2 hours of taking Glucomannan.
Echinacea Purpurea
(Echinacea)
Drug Digest (summary below)
Purdue University
Summary
Even though they are not proven to be effective, echinacea products are among
the most widely used herbals in the world. They are taken by mouth to enhance immune system response and to lessen the duration
and symptoms of colds and flu. When applied to the skin, they are used to relieve conditions such as eczema, insect bites,
and psoriasis.
Risks
Ecinacea’s potential to increase immune function may worsen autoimmune
conditions such as multiple sclerosis and type 1 diabetes. Individuals with autoimmune diseases should not use echinacea.
Pregnant and breast-feeding women and small children should also avoid its use.
Side Effects
Side effects reported from taking echinacea by mouth include nausea and diarrhea.
Some individuals may develop an allergic reaction from taking echinacea, applying topical forms, or handling the plant.
Interactions
Echinacea may interact with drugs that suppress the immune system and with
several other drugs that are processed by the body in the same way that echinacea is processed. It may interfere with the
breakdown of caffeine. If you are not sure whether a drug you take will interact with echinacea, ask your doctor or pharmacist
before you begin to use echinacea. Make sure to mention any non-prescription and herbal products that you take as well as
prescription medications.
Ananas Comosus (Pineapple)
Purdue University
Pineapple (bromelain) is pretty safe with rare cases of heart failure, coma,
and increased menstrual flow.
Allium Sativum (Garlic)
Drug Digest (summary below)
Purdue University
It is believed that garlic may relax blood vessels, causing them to widen
and allowing blood to flow more easily. In addition, the thickness of the blood may be reduced by taking garlic, which may
block the body's production of thromboxane, a chemical involved in blood clotting and blood vessel tightening.
Summary
Some limited clinical evidence seems to show that garlic taken orally can
help moderately to reduce high cholesterol and high blood pressure. Less evidence supports its effectiveness in preventing
heart disease, enhancing immune function, and protecting against some types of cancer.
Risks
Garlic in recommended amounts seems to have few risks. People who have bleeding
disorders or who take medications to thin the blood, should be aware that taking large amounts of garlic may further reduce
the blood's ability to clot.
Side Effects
In the amounts used in food or recommended medicinal doses, garlic has few
side effects. Large amounts, however, have been associated with irritated mouth or stomach. A few people may have asthma or
rash from handling the garlic plants for a long time or in large amounts. If it is left in contact with the skin for extended
periods of time, garlic may cause irritation or burns.
Interactions
If it is taken at the same time as drugs or other herbs that "thin the blood"'
very large amounts of garlic taken by mouth could increase the amount of time that blood needs to clot. Garlic in high amounts
may interfere with some antiviral and antidiabetic medications, as well as with other drugs, such as acetaminophen, that are
broken down by the same liver enzymes as garlic. It may increase the activity of drugs that lower blood sugar.
Zingiber Officinale
(Ginger)
Drug Digest (summary below)
Summary
Aside from its value as a spice and flavoring agent, ginger is used in western
countries mainly to relieve nausea. It may also have some ability to relieve stomach cramps and other gastrointestinal complaints.
Risks
Supplemental ginger should be avoided by women who are breast-feeding, individuals
who have diabetes or gallstones, and children less than 2 years of age. Pregnant women should consult a health professional
before taking ginger in supplemental amounts.
Side Effects
In humans, the medical use of ginger has been associated with minor side
effects such as a tingling feeling in the mouth and diarrhea. In laboratory animals, however, extremely high doses of ginger
may have caused heart rhythm changes and central nervous system impairment.
Interactions
Although the amounts of ginger used in foods are not thought to interact
with drugs, other herbal products, or foods; very large amounts of ginger could interfere with:
- Anticoagulant or antiplatelet drugs and herbals
- Antacids and drugs that reduce stomach acid
- Drugs for heart conditions
- High blood pressure drugs
- Insulin and oral drugs for diabetes
Ginkgo Biloba (Ginkgo)
Drug Digest (summary below)
Summary
The leaves of the ginkgo tree contain chemicals that decrease the thickness
of blood and increase the size of blood vessels. The resulting increased blood flow improves oxygen levels which may relieve
conditions such as memory loss, intermittent claudication, macular degeneration, and glaucoma.
Roasted ginkgo seeds may sometimes be used to treat chronic respiratory conditions
such as asthma.
Risks
Due to its ability to inhibit blood clotting, ginkgo should be avoided by
individuals with bleeding disorders. Since it may precipitate seizures, ginkgo should not be taken by individuals with epilepsy.
And because ginkgo may affect blood sugar levels, individuals with diabetes should not take it.
Pregnant women, women who are breast-feeding, and young children may want
to avoid ginkgo leaf because too little is known about its possible effects for those groups. Ginkgo seeds may cause seizures;
however, so they should not be given to children and for adults they should be limited to no more than 10 per day for just
a few days. Fresh ginkgo seeds and ginkgo fruits should never be taken by mouth.
Side Effects
Either ginkgo leaf or – more likely – ginkgo seed may initiate
seizures.
Taking ginkgo leaf preparations may cause unexpected bleeding into the eyes
or under the skin. Mild headache, muscle weakness, or stomach upset may also be attributed to using ginkgo leaf.
Consuming any amount of fresh ginkgo seeds or more than about 10 roasted
seeds at one time has resulted in breathing difficulty, unconsciousness, or death.
Eating or touching ginkgo fruits may be associated with skin irritation,
redness, or swelling.
Interactions
Ginkgo leaf extract may increase the effects of drugs and herbals that reduce
blood clotting. It may interfere with insulin and oral drugs or herbs that affect blood sugar.
Taking either ginkgo leaf or ginkgo seed may decrease the effects of anticonvulsant
drugs. They may also increase the chance of a seizure if they are taken with several different types of prescription and non-prescription
drugs or herbal products that may also make seizures more likely to occur.
Panax Ginseng (Ginseng)
Drug Digest (summary below)
Summary
Taken most commonly as an adaptogen to help the body resist stress, Panax
ginseng has been studied for improving memory, treating asthma, and enhancing immune function. It may also help to reduce
levels of blood sugar and blood cholesterol. Either orally or topically, it may treat erectile dysfunction and it may also
help to relieve some types of male infertility. Possible estrogenic effects need further investigation.
Risks
Individuals who have heart conditions or cancers of the breast, ovaries,
prostate, or uterus should not take Panax ginseng. Pregnant women, infants, and young children should also avoid taking it.
Individuals who have diabetes or insomnia should be careful if they decide to take Panax ginseng.
Side Effects
Rarely, newborn babies who are given Panax ginseng have developed an intoxication-like
condition. In adults, rare cases of hepatitis or inflamed blood vessels in the brain have been attributed to taking it. One
case of possible severe allergy to Panax ginseng resulted in breathing problems, low blood pressure, and sudden rash. More
often, Panax ginseng is associated with milder and temporary side effects such as diarrhea, heart rate changes, insomnia,
and nervousness.
Interactions
Panax ginseng may interfere with many prescription drugs, non-prescription
products, and herbals, including:
- albuterol
- caffeine
- Central nervous system stimulants
- Drugs and herbals that affect blood clotting
- Drugs and herbals used for the treatment of diabetes
- Drugs used to treat schizophrenia
- MAO inhibitors
- theophylline and related drugs for asthma
- Viagra
Llex Paraguariensis
(Yerba Mate)
Tropical Plant Database (summary below)
In addition to its standing as a popular beverage, yerba mate is used as
a tonic, diuretic, and as a stimulant to reduce fatigue, suppress appetite, and aid gastric function in herbal medicine systems
throughout South America. It also has been used as a depurative (to promote cleansing and excretion of waste). In Brazil,
mate is said to stimulate the nervous and muscular systems and is used for digestive problems, renal colic, nerve pain, depression,
fatigue, and obesity. A poultice of the leaves also is applied topically to anthrax skin ulcers (for which mate's tannin content
- highly astringent - may be the reasoning behind this use).
Main Actions (in order):
stimulant, tonic (tones, balances, strengthens overall body functions), thermogenic (increase fat-burning), nervine (balances/calms
nerves), anti-allergy
Main Uses:
- as a stimulant (for its caffeine content)
- as an overall tonic (tones, balances, strengthens the body) and digestive
aid
- for obesity and as part of weight loss regimens
- as a general nervine (balances/calms nerves) for nerve pain, nervous fatigue,
and depression
- for allergies and sinusitis
Properties/Actions Documented by Research: anti-inflammatory,
antioxidant, antispasmodic, bile stimulant, stimulant, thermogenic (increases fat burning), vasodilator
Other Properties/Actions Documented by Traditional Use: anti-allergy, antidepressant, appetite suppressant, blood cleanser, cardiotonic (tones,
balances, strengthens the heart), central nervous system stimulant, digestive stimulant, hypotensive (lowers blood pressure),
nervine (balances/calms nerves), neurasthenic (reduces nerve pain), neuroprotective (protects brain cells), purgative (strong
laxative)
Cautions: It contains
natural caffeine. Don't use if allergic to caffeine or zanthines
Filipendula Ulmaria
(Meadowsweet)
Drug Digest (summary below)
Summary
Meadowsweet is used most frequently as supportive therapy for the common
cold. It may also be somewhat effective for the treatment of various stomach conditions such as heartburn and ulcers.
Risks
Because meadowsweet has been associated with causing constriction of the
airways in the lungs, it should be avoided in individuals with asthma. Pregnant women also avoid meadowsweet due to the possibility
of causing uterine contractions.
Children and individuals with aspirin and sulfite allergies should not take
meadowsweet due to its salicylate component.
Side Effects
Although few side effects have been reported from meadowsweet, it may cause
nausea or stomach upset in individuals who use it.
Interactions
Some evidence suggests that meadowsweet may increase both the effects and
the risk of side effects from narcotic analgesics.
The heparin-like and salicylate compounds in meadowsweet may increase
the risk of bleeding when it is used with warfarin, other anticoagulant or antiplatelet drugs, aspirin, or herbal products
that also have an anticoagulant effect.
Hypericum Perforatum
(St. John’s Wort
Drug Digest (summary below)
Summary
Currently, St. John's wort is best known for mild antidepressant effects,
but it is also being studied to treat other mood disorders such as anxiety and obsessive-compulsive disorder. It may have
antiviral and antibacterial effects and it has been used topically for skin injuries.
Risks
St. John's wort may cause the rejection of transplanted organs, therefore
transplant recipients should not take it. Alzheimer's patients, individuals with mental illnesses, couples trying to conceive
a child, and pregnant or breast-feeding women should also avoid it.
Side Effects
Rarely, taking St. John's wort may be associated with "serotonin syndrome"
-- an excess of serotonin that may cause confusion, hallucinations, and seizures.
Both oral and topical forms of St. John's wort may make the skin more likely
to sunburn. Other possible side effects are generally mild. They may include drowsiness, headache, rash, and upset stomach.
Interactions
If St. John's wort is taken with psoralens or certain antibiotics, the chance
of sunburn may increase.
St. John's wort may interfere with a large number of drugs and herbal products
including:
Alcohol
- Allergy drugs such as fexofenadine (Allegra)
- Antidepressants
- Antifungal drugs such as itraconazole (Sporanox) and ketoconazole (Nizoral)
- Cancer drugs such as etoposide, paclitaxel, vinblastine, or vincristine
- Dextromethorphan
- Digoxin
- Drugs for high cholesterol such as lovastatin
- Immunosuppressants such as cyclosporine and Prograf
- Iron
- Non-nucleoside reverse transcriptase inhibitors
- Oral contraceptives
- Protease inhibitors
- Reserpine
- Sedating drugs and herbals
- Theophylline
- Triptans such as Imitrex
Valeriana Officinalis
(Valerian)
Drug Digest (summary below)
Purdue University
Summary
Supported by some evidence from clinical studies, valerian is now promoted
mainly for its sedative and soothing effects.
Risks
Rare instances of liver damage have been attributed to the use of valerian.
If you are taking valerian, you should report jaundice, abdominal tenderness, or other signs of possible liver injury to your
doctor immediately.
Ingesting large amounts of valerian may result in cramps, temporary loss
of muscle control and very low body temperature.
Side Effects
In recommended doses, valerian could cause some residual drowsiness and intense
dreams. For some people, it may produce a contradictory stimulating effect, which may even include insomnia, instead of relaxation.
Interactions
Because it promotes sleepiness, valerian can increase the sedation associated
with certain prescription drugs, non-prescription drugs, other dietary supplements, and alcohol. Be careful when using it
at the same time as you are taking drugs for anxiety, colds and coughs, epilepsy, or insomnia. Many other medications cause
drowsiness, so check with your doctor before taking valerian with any prescription, non-prescription, or herbal product.
Valerian can also interfere with the way the body breaks down drugs in the
liver. You should discuss your other medications with your doctor or pharmacist before you begin to take valerian.
RESOURCES
Check Potential Drug Interactions at Drug Digest
All summaries of the herbs listed above have been cited from the following:
Drug Digest ( www.drugdigest.org)
Purdue University ( www.hort.purdue.edu)
Tropical Plant Database ( www.rain-tree.com)
Vitacost ( www.vitacost.com)
Holistic Online ( www.holisticonline.com)
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